Dave Grohl tunes to Drop D for this. Classic Marshall crunch tone, mid-heavy, nothing too fancy.
Signal Chain
Marshall JCM800→4x12 V30→Output
AmpMarshall JCM800
bass
5
gain
7
mids
7
treble
6
presence
5
Cab / IR4x12 V30
micSM57
mic positioncenter cap
Notes
Drop D tuning makes the low string power chords ring beautifully. The chorus has a massive wall of sound.
Don't have Helix?
See the same signal chain mapped to another platform. Knob values carry over as starting points — gain ranges differ between platforms. NAM/TONEX users: the real gear names are what to search for as captures.