The main riff is primarily a bass line, but the guitar fills are huge and distorted. Mesa Dual Rectifier gives the right heaviness.
Signal Chain
Mesa Boogie Dual Rectifier→Mesa 4x12 V30→Output
AmpMesa Boogie Dual Rectifier
bass
6
gain
8
mids
5
treble
7
channelModern
presence
6
Cab / IRMesa 4x12 V30
micSM57
mic positioncenter cap
Notes
Heavy, saturated distortion. The guitar locks with the bass on the main riff.
Don't have Helix?
See the same signal chain mapped to another platform. Knob values carry over as starting points — gain ranges differ between platforms. NAM/TONEX users: the real gear names are what to search for as captures.